33 Hear another parable: There was a certain householder (land owner/farmer), which planted a vineyard, and hedged it round about, and digged a winepress in it, and built a tower, and let it out to husbandmen (farmers), and went into a far country:
34 And when the time of the fruit drew near, he sent his servants to the husbandmen, that they might receive the fruits of it.
35 And the husbandmen took his servants, and beat one, and killed another, and stoned another.
36 Again, he sent other servants more than the first: and they did unto them likewise.
37 But last of all he sent unto them his son, saying, They will reverence my son.
38 But when the husbandmen saw the son, they said among themselves, This is the heir; come, let us kill him, and let us seize on his inheritance.
39 And they caught him, and cast him out of the vineyard, and slew him.
40 When the lord therefore of the vineyard cometh, what will he do unto those husbandmen?
41 They say unto him, He will miserably destroy those wicked men, and will let out his vineyard unto other husbandmen, which shall render him the fruits in their seasons.
42 Jesus saith unto them, Did ye never read in the scriptures, The stone which the builders rejected, the same is become the head of the corner: this is the Lord's doing, and it is marvellous in our eyes?
43 Therefore say I unto you, The kingdom of God shall be taken from you, and given to a nation bringing forth the fruits thereof.
44 And whosoever shall fall on this stone shall be broken: but on whomsoever it shall fall, it will grind him to powder.
45 And when the chief priests and Pharisees had heard his parables, they perceived that he spake of them.
46 But when they sought to lay hands on him, they feared the multitude - Jesus Christ – Matthew 21:33–46
This parable has a very deep meaning, but I will fish it out the best I can. I believe this is a prophesy that Jesus is telling about his future crucifixion. God gave man the Word (Bible) and man wasn't listening so he sent his own Son, Jesus. This parable is saying that the Kingdom of God will be taken away from mankind, who will reject it (Jesus), and be given to the select few (as indicated in other parables). Regarding the scriptures about the stone that the builders rejected, it can be found in 1 Peter 2:6-8:
"6 For in Scripture it says: See, I lay a stone in Zion, a chosen and precious cornerstone, and the one who trusts in him will never be put to shame.
: 7 Now to you who believe, this stone is *precious. But to those who do not believe, 'The stone the builders rejected has become the capstone'."
Here is how cornerstone and capstone can be interpreted. A cornerstone is the foundation stone and the first stone set, becoming the most important stone of a building. A capstone is the highest stone on a wall or building. To believers, Jesus is the cornerstone, but he is saying to the unbelievers that, to them, the stone is the capstone, which means, the highest level that one can achieve.
At first glance, this parable can be hard to understand, however, the gist of the meaning is that God will give the Kingdom of God to those who believe in Him and take it away from the wicked. To those who don't believe, they must know that the Kingdom of God is the highest and most revered level. God has said that he is the alpha (first) and omega (last), just like the cornerstone (first), and capstone (last).